Department Combustion- and Particle Technology

Working Group: Exposure Systems

Fine dusts, gas-borne nanoparticles and aerosols from technical processes in general are the focus of environmental issues and workplace assessments and are therefore current research topics. In the Exposure Systems working group, the potential risks from the release of critical substances are also investigated as part of the examination of new materials throughout their life cycle. For subsequent testing by KIT partner institutes for toxic effects, these aerosols are deposited on lung cell cultures in a defined manner. Both the aerosols and the applied surface dose are determined using various methods. Both standard technologies and in-house developments such as online dose measurement using a quartz crystal microbalance are used. In addition, the processes are simulated numerically.

Fields of activity

Projects

Laboratories and pilot plants

Expositionssystem
Aerosol laboratory
Particle measurement technology (equipment overview)
Laboratory for microscopy and image analysis
Wood burning stove
Aerosol-Trockenturm DIN 3491 Blatt 3
Online-Dosiermessung (QCM)

Publications

2024

Numerical Simulation of Fiber Deposition Behavior in an Air-Liquid Interface Exposure System
Klein, S.; Mülhopt, S.; Gutmann, B.; Schlager, C.; Krebs, T.; Stapf, D.
2024. EAC 2024

Numerical Simulation of Fiber Deposition Behavior in an Air-Liquid Interface Exposure System
Klein, S.; Mülhopt, S.; Gutmann, B.; Schlager, C.; Krebs, T.; Stapf, D.
2024, August 27. European Aerosol Conference (EAC 2024), Tampere, Finland, August 25–30, 2024

Numerical Simulation of Fibre Dose in an Air-Liquid-Interface Exposure System
Mülhopt, S.; Klein, S.; Gutmann, B.; Schlager, C.; Krebs, T.; Stapf, D.
2024. European Aerosol Conference 2024

Numerical Simulation of Fibre Dose in an Air-Liquid-Interface Exposure System
Mülhopt, S.; Klein, S.; Gutmann, B.; Schlager, C.; Krebs, T.; Stapf, D.
2024, August 27. European Aerosol Conference (EAC 2024), Tampere, Finland, August 25–30, 2024

Numerical Simulation of Fibre Dose in an Air-Liquid-Interface Exposure System
Mülhopt, S.; Klein, S.; Gutmann, B.; Schlager, C.; Krebs, T.; Stapf, D.
2024, July 3. 9th UFP Conference : International Symposium on Ultrafine Particles - Air Quality and Climate (2024), Brussels, Belgium, July 3–4, 2024

2023

Kaminöfen - gemütlich und gefährlich
Mülhopt, S.; Dittler, A.
2023

Systems toxicology of complex wood combustion aerosol reveals gaseous carbonyl compounds as critical constituents
Dilger, M.; Armant, O.; Ramme, L.; Mülhopt, S.; Sapcariu, S. C.; Schlager, C.; Dilger, E.; Reda, A.; Orasche, J.; Schnelle-Kreis, J.; Conlon, T. M.; Yildirim, A. Ö.; Hartwig, A.; Zimmermann, R.; Hiller, K.; Diabaté, S.; Paur, H.-R.; Weiss, C.
2023. Environment International, 179, Art.-Nr.: 108169. doi:10.1016/j.envint.2023.108169

Comparing the Toxicological Responses of Pulmonary Air–Liquid Interface Models upon Exposure to Differentially Treated Carbon Fibers
Friesen, A.; Fritsch-Decker, S.; Mülhopt, S.; Quarz, C.; Mahl, J.; Baumann, W.; Hauser, M.; Wexler, M.; Schlager, C.; Gutmann, B.; Krebs, T.; Goßmann, A.-K.; Weis, F.; Hufnagel, M.; Stapf, D.; Hartwig, A.; Weiss, C.
2023. International Journal of Molecular Sciences, 24 (3), Art.-Nr.: 1927. doi:10.3390/ijms24031927

2022

Characterisation and biological responses of inhalable aerosols from carbon fibres
Mülhopt, S.
2022. IAC Book of Abstracts 2022, 27

Characterisaton of inhalable aerosols from carbon fibres
Mülhopt, S.; Hauser, M.; Wexler, M.; Mahl, J.; Baumann, W.; Diabaté, S.; Fritsch-Decker, S.; Weiss, C.; Friesen, A.; Hufnagel, M.; Hartwig, A.; Gutmann, B.; Schlager, C.; Krebs, T.; Goßmann, A.-K.; Weis, F.; Stapf, D.
2022, September. 11th International Aerosol Conference (IAC 2022), Athens, Greece, September 4–9, 2022

Entwicklung von Rückbau- und Recyclingstandards für Rotorblätter : Abschlussbericht [Kurztitel: Aufbereitung von Rotorblättern]
Kühne, C.; Stapf, D.; Holz, P.; Baumann, W.; Mülhopt, S.; Wexler, M.; Hauser, M.; Kalkreuth, J.; Mahl, J.; Zeller, M.; Volk, R.; Stallkamp, C.; Steffl, S.; Schultmann, F.; Schweppe, R.; Seiler, E.; Forberger, J.; Brantsch, P.; Brenken, B.; Beckmann, M.
2022. Umweltbundesamt (UBA). doi:10.5445/IR/1000151175

Gene Expression Profiling of Mono- and Co-Culture Models of the Respiratory Tract Exposed to Crystalline Quartz under Submerged and Air-Liquid Interface Conditions
Friesen, A.; Fritsch-Decker, S.; Hufnagel, M.; Mülhopt, S.; Stapf, D.; Weiss, C.; Hartwig, A.
2022. International Journal of Molecular Sciences, 23 (14), 7773. doi:10.3390/ijms23147773

Characterisation of inhalable aerosols from carbon fibres
Mülhopt, S.
2022, July 5. 8th UFP Conference : International Symposium on Ultrafine Particles - Air Quality and Climate (2022), Brussels, Belgium, July 5–6, 2022

Characterisation of inhalable aerosols from carbon fibres
Mülhopt, S.; Hauser, M.; Wexler, M.; Mahl, J.; Baumann, W.; Fritsch-Decker, S.; Weiss, C.; Friesen, A.; Hufnagel, M.; Hartwig, A.; Gutmann, B.; Schlager, C.; Krebs, T.; Goßmann, A.-K.; Weis, F.; Stapf, D.
2022. 8th EFCA International Symposium on Ultrafine Particles - Air Quality and Climate. Abstract I.5, 52, European Federation of Clean Air and Environmental Protection Associations (EFCA)

Comparing α-Quartz-Induced Cytotoxicity and Interleukin-8 Release in Pulmonary Mono- and Co-Cultures Exposed under Submerged and Air-Liquid Interface Conditions
Friesen, A.; Fritsch-Decker, S.; Hufnagel, M.; Mülhopt, S.; Stapf, D.; Hartwig, A.; Weiss, C.
2022. International Journal of Molecular Sciences, 23 (12), 6412. doi:10.3390/ijms23126412

CFC - Carbon FibreCycle - Carbonfasern im Kreislauf - Freisetzungsverhalten und Toxizität bei thermischer und mechanischer Behandlung : Laufzeit: 01.01.2019-30.06.2022 : Sachbericht zum Verwendungsnachweis
Baumann, W.; Fritsch-Decker, S.; Hauser, M.; Mahl, J.; Mülhopt, S.; Stapf, D.; Weiss, C.; Wexler, M.
2022. Karlsruher Institut für Technologie (KIT). doi:10.2314/KXP:188246253X

2021

Agglomeration State of Titanium-Dioxide (TiO2) Nanomaterials Influences the Dose Deposition and Cytotoxic Responses in Human Bronchial Epithelial Cells at the Air-Liquid Interface
Murugadoss, S.; Mülhopt, S.; Diabaté, S.; Ghosh, M.; Paur, H.-R.; Stapf, D.; Weiss, C.; Hoet, P. H.
2021. Nanomaterials, 11 (12), 3226. doi:10.3390/nano11123226

CFC - CarbonFibreCycle Carbonfasern im Kreislauf – Freisetzungsverhalten und Toxizität bei thermischer und mechanischer Behandlung
Mülhopt, S.; Weiss, C.; Adler, S.; Baumann, W.; Diabaté, S.; Fritsch-Decker. Susanne; Friesen, A.; Goßmann, A.-K.; Gutmann, B.; Güttler, B.; Hauser, M.; Hartwig, A.; Hee, J.; Krebs, T.; Mahl, J.; Quicker, P.; Schlager, C.; Weis, F.; Wexler, M.; Stapf, D.
2021. "NanoCare‐Clustertreffen 2021 - Vorstellung der Projekte aus der BMBF‐Fördermaßnahme NanoCare4.0. Book of Abstracts". Hrsg. DECHEMA Gesellschaft für Chemische Technik und Biotechnologie e.V

Impact of Nanocomposite Combustion Aerosols on A549 Cells and a 3D Airway Model
Hufnagel, M.; May, N.; Wall, J.; Wingert, N.; Garcia-Käufer, M.; Arif, A.; Hübner, C.; Berger, M.; Mülhopt, S.; Baumann, W.; Weis, F.; Krebs, T.; Becker, W.; Gminski, R.; Stapf, D.; Hartwig, A.
2021. Nanomaterials, 11 (7), Art. Nr.: 1685. doi:10.3390/nano11071685

Verwertungsoptionen für Carbonfasern am Ende des Lebenszyklus
Stapf, D.; Baumann, W.; Gehrmann, H.-J.; Mülhopt, S.; Weiss, C.; Wexler, M.
2021, February 25. 4. Fachtagung Composite Recycling & LCA (2021), Online, February 25, 2021

Innovativer Werkstoff, gefährlich für die Lunge? = An Innovative Material – But A Danger To The Lungs?
Mülhopt, S.
2021. lookKIT, (2), 54

Air–Liquid Interface Exposure of Lung Epithelial Cells to Low Doses of Nanoparticles to Assess Pulmonary Adverse Effects
Diabaté, S.; Armand, L.; Murugadoss, S.; Dilger, M.; Fritsch-Decker, S.; Schlager, C.; Béal, D.; Arnal, M.-E.; Biola-Clier, M.; Ambrose, S.; Mülhopt, S.; Paur, H.-R.; Lynch, I.; Valsami-Jones, E.; Carriere, M.; Weiss, C.
2021. Nanomaterials, 11 (1), Art. Nr.: 65. doi:10.3390/nano11010065

2020

A novel TEM grid sampler for airborne particles to measure the cell culture surface dose
Mülhopt, S.; Schlager, C.; Berger, M.; Murugadoss, S.; Hoet, P. H.; Krebs, T.; Paur, H.-R.; Stapf, D.
2020. Scientific reports, 10 (1), Art-Nr.: 8401. doi:10.1038/s41598-020-65427-w

Inhalable aerosols from carbon fibres
Mülhopt, S.; Hauser, M.; Wexler, M.; Baumann, W.; Diebaté, S.; Fritsch-Decker, S.; Weiss, C.; Friesen, A.; Hufnagel, M.; Hartwig. Andrea; Gutmann, B.; Schlager, C.; Krebs, T.; Goßmann, A.-K.; Weis, F.; Stapf, D.
2020. doi:10.5445/IR/1000125510

Potentials and Risks in the Recycling and Recovery of Carbon Fibers
Baumann, W.; Beuchle, G.; Gehrmann, H.-J.; Hauser, M.; Merz, D.; Mülhopt, S.; Weiss, C.; Stapf, D.
2020, September 15. (M. Wexler, Ed.), 2nd Advanced Materials Online Conference (2020), Online, September 15, 2020

Inhalable aerosols from carbon fibres
Mülhopt, S.; Hauser, M.; Wexler, M.; Baumann, W.; Diabaté, S.; Fritsch-Decker, S.; Weiss, C.; Friesen, A.; Hufnagel, M.; Hartwig, A.; Gutmann, B.; Schlager, C.; Krebs, T.; Goßmann, A.-K.; Weis, F.; Stapf, D.
2020, September 3. European Aerosol Conference (EAC 2020), Online, August 31–September 4, 2020

Toxicity assessment of pristine and thermally treated carbon fibres
Diabaté, S.; Fritsch-Decker, S.; Mülhopt, S.; Wexler, M.; Hauser, M.; Baumann, W.; Hufnagel, M.; Friesen, A.; Hartwig, A.; Stapf, D.; Weiss, C.
2020. Naunyn-Schmiedeberg’s archives of pharmacology, 393 (S1), S89. doi:10.1007/s00210-020-01828-y

2019

Stand der Untersuchungen zum Freisetzungsverhalten von Carbonfasern in thermischen Prozessen
Stapf, D.; Baumann, W.; Hauser, M.; Mülhopt, S.; Weiss, C.; Wexler, M.
2019, September 19. Umweltbundesamt Fachaustausch: Aufbereitung und Verwertung carbonfaserhaltiger Abfälle (2019), Dessau, Germany, September 19–20, 2019

Agglomeration state of titanium-di-oxide (TiO₂) nanomaterials influences the toxicity/biological responses in human bronchial epithelial cells at the air-liquid interface
Murugadoss, S.; Diabaté, S.; Mülhopt, S.; Paur, H.-R.; Brassinne, F.; Mast, J.; Godderis, L.; Weiss, C.; Hoet, P.
2019, September 9. 55th Congress of the European Societies of Toxicology (EUROTOX 2019), Helsinki, Finland, September 8–11, 2019

Testing of Aerosols for Lung Toxicity by In-Vitro Studies at the Air-Liquid Interface for up to 24 hours
Mülhopt, S.; Diabaté, S.; Schlager, C.; Dilger, M.; Berger, M.; Krebs, T.; Weiss, C.; Paur, H.-R.
2019. Asian Aerosol Conference (AAC 2019), Hong Kong, Hong Kong, May 27–30, 2019

Testing of Aerosols for Lung Toxicity by In-Vitro Studies at the Air-Liquid Interface for up to 24 hours
Mülhopt, S.; Diabaté, S.; Schlager, C.; Krebs, T.; Stapf, D.
2019. European Aerosol Conference (EAC 2019), Gothenburg, Sweden, August 25–30, 2019

Nanoparticle Release from Thermal Decomposition of Polymer Nanocomposites and the Biological Potential of the Emissions
Mülhopt, S.; Teuscher, N.; Hufnagel, M.; Wingert, N.; Baumann, W.; Hauser, M.; Garcia-Käufer, M.; Schlager, C.; Berger, M.; Krebs, T.; Paur, H.-R.; Gminski, R.; Hartwig, A.; Stapf, D.
2019. 7th UFP Conference : International Symposium on Ultrafine Particles - Air Quality and Climate (2019), Brussels, Belgium, May 15–16, 2019

Testing of Aerosols for Lung Toxicity by In-Vitro Studies at the Air-Liquid Interface for up to 24 Hours
Mülhopt, S.; Diabaté, S.; Schlager, C.; Berger, M.; Dilger, M.; Krebs, T.; Paur, H.-R.; Weiss, C.; Stapf, D.
2019. 7th UFP Conference : International Symposium on Ultrafine Particles - Air Quality and Climate (2019), Brussels, Belgium, May 15–16, 2019

2018

Inter-laboratory comparison of nanoparticle size measurements using dynamic light scattering and differential centrifugal sedimentation
Langevin, D.; Lozano, O.; Salvati, A.; Kestens, V.; Monopoli, M.; Raspaud, E.; Mariot, S.; Salonen, A.; Thomas, S.; Driessen, M.; Haase, A.; Nelissen, I.; Smisdom, N.; Pompa, P. P.; Maiorano, G.; Puntes, V.; Puchowicz, D.; Stępnik, M.; Suárez, G.; Riediker, M.; Benetti, F.; Mičetić, I.; Venturini, M.; Kreyling, W. G.; Zande, M. van der; Bouwmeester, H.; Milani, S.; Rädler, J. O.; Mülhopt, S.; Lynch, I.; Dawson, K.
2018. NanoImpact, 10, 97–107. doi:10.1016/j.impact.2017.12.004

Emissions from a modern log wood masonry heater and wood pellet boiler : Composition and biological impact on air-liquid interface exposed human lung cancer cells
Kanashova, T.; Sippula, O.; Oeder, S.; Streibel, T.; Passig, J.; Czech, H.; Kaoma, T.; Sapcariu, S. C.; Dilger, M.; Paur, H.-R.; Schlager, C.; Mülhopt, S.; Weiss, C.; Schmidt-Weber, C.; Traidl-Hoffmann, C.; Michalke, B.; Krebs, T.; Karg, E.; Jakobi, G.; Scholtes, S.; Schnelle-Kreis, J.; Sklorz, M.; Orasche, J.; Müller, L.; Reda, A.; Rüger, C.; Neumann, A.; Abbaszade, G.; Radischat, C.; Hiller, K.; Grigonyte, J.; Kortelainen, M.; Kuuspalo, K.; Lamberg, H.; Leskinen, J.; Nuutinen, I.; Torvela, T.; Tissari, J.; Jalava, P.; Kasurinen, S.; Uski, O.; Hirvonen, M.-R.; Buters, J.; Dittmar, G.; Jokiniemi, J. K.; Zimmermann, R.
2018. Journal of Molecular and Clinical Medicine, 1 (1), 23–35. doi:10.31083/j.jmcm.2018.01.004

Behavior of nanoparticles and polymer nanocomposites during lab-scale combustion within the project „ProCycle“
Teuscher, N.; Baumann, W.; Hauser, M.; Mülhopt, S.; Paur, H.-R.; Stapf, D.
2018. International Conference on Nanotoxicology (NanoTox 2018), Neuss, Germany, August 18–September 21, 2018

Characterization of Nanoparticle Batch-To-Batch Variability
Mülhopt, S.; Diabaté, S.; Dilger, M.; Adelhelm, C.; Anderlohr, C.; Bergfeldt, T.; Gómez de la Torre, J.; Jiang, Y.; Valsami-Jones, E.; Langevin, D.; Lynch, I.; Mahon, E.; Nelissen, I.; Piella, J.; Puntes, V.; Ray, S.; Schneider, R.; Wilkins, T.; Weiss, C.; Paur, H.-R.
2018. Nanomaterials, 8 (5), Article: 311. doi:10.3390/nano8050311

Systems toxicology of wood smoke
Dilger, M.; Ramme, L.; Sapcariu, S. C.; Mülhopt, S.; Schlager, C.; Reda, A.; Orasche, J.; Armant, O.; Maser, E.; Hartwig, A.; Zimmermann, R.; Hiller, K.; Diabate, S.; Paur, H. R.; Weiss, C.
2018. 26. Analytica : Internationale Leitmesse für Labortechnik, Analytik, Biotechnologie und analytica Conference (2018), Munich, Germany, April 10–13, 2018

2017

Lung toxicity testing of aerosols for in-vitro studies at the air-liquid-interface with integrated dose monitoring
Mülhopt, S.; Diabate, S.; Schlager, C.; Marco, D.; Berger, M.; Krebs, T.; Weiss, C.; Paur, H.-R.
2017. Nanosafety 2017, Saarbrücken, October 11-13, 2017

Characterization of nanoparticles and polymer nanocomposites in flames for subsequent studies on health effects
Teuscher, N.; Hufnagel, M.; Baumann, W.; Hauser, M.; Mülhopt, S.; Berger, M.; Schlager, C.; Krebs, T.; Garcia-Käufer, M.; Gminski, R.; Wingert, N.; Hartwig, A.; Paur, H.-R.; Stapf, D.
2017. European Aerosol Conference (EAC 2017), Zurich, Switzerland, August 27–September 1, 2017

In Vitro Exposure Systems to Assess the Toxicity of Airborne Substances
Krebs, T.; Mülhopt, S.; Diabate, S.; Schlager, C.; Paur, H.-R.; Dilger, M.
2017. Biomedical Application of Nanoparticles. Ed.: B.H. Rihn, 209–222, CRC Press

Novel aerosol exposure devices for in vitro toxicity testing of airborne pollutants at the air/liquid interface
Mülhopt, S.; Krebs, T.; Schlager, C.; Dilger, M.; Weiss, C.; Diabaté, S.; Paur, H.-R.
2017. 3rd International Conference on Toxicological Alternatives & Translational Toxicology 2017, Nanjing, China, 9th - 12th July 2017

Molecular biological effects and toxicity of combustion aerosol emissions on air/liquid-interface exposed human and murine lung cells
Zimmermann, R.; Dittmar, T. G.; Kanashova, T.; Buters, J.; Öder, S.; Huber, A.; Paur, H.; Mülhopt, S.; Dilger, M.; Weiß, C.; Buchholz, B.; Stengel, B.; Hiller, K.; Sapccariu, S. C.; Berube, K. A.; Wlodarcyzk, A. J.; Michalke, B.; Krebs, T.; Kelbg, M.; Tiggesbäumker, J.; Streibel, T.; Karg, E.; Scholtes, S.; Schnelle-Kreis, J.; Lintelmann, J.; Sklorz, M.; Klingbeil, S.; Orasche, J.; Müller, L.; Rheda, A.; Passig, J.; Gröger, T.; Abbaszade, G.; Smita, S.; Orasche, J.; Uski, O.; Jalava, P.; Happo, M.; Hartikainen, A.; Lamberg, H.; Hirvonen, M.-R.; Kasurinen, S.; Sippula, O.; Jokiniemi, J.
2017. European Aerosol Conference (EAC 2017), Zurich, Switzerland, 27th August - 1st September 2017

Toxicity of wood smoke particles in human lung epithelial cells: The role of PAHs, soot and zinc
Dilger, M.; Orasche, J.; Schlager, C.; Mülhopt, S.; Zimmermann, R.; Paur, H.-R.; Diabaté, S.; Weiss, C.
2017. European Aerosol Conference 2017, Zürich, Schweiz, 27.08.-01.09.2017

Particle mass monitoring by Quartz Crystal Microbalance using electrostatic deposition enhancement
Mülhopt, S.; Schlager, C.; Krebs, T.; Berger, M.; Paur, H.-R.
2017. European Aerosol Conference (EAC), Zurich, Schweiz, Switzerland, 27th August - 1st September 2017

Lung Toxicity of Aerosols the Air-Liquid Interface with Integrated Dose Monitoring
Mülhopt, S.; Diabate, S.; Schlager, C.; Dilger, M.; Weiss, C.; Krebs, T.; Paur, H.-R.
2017. 6th International Symposium on Ultrafine Particles Air Quality and Climate, Brussels, B, May 10-11, 2017

Effects of Cerium oxide nanoparticle aerosol on human lung cells exposed at the air-liquid-interface
Mülhopt, S.; Diabaté, S.; Schlager, C.; Dilger, M.; Murugadoss, S.; Weiss, C.; Krebs, T.; Tang, S.; Gooden, P.; Koekemoer, L.-A.; Dekkers, S.; Cassee, F.; Paur, H.-R.
2017. New Tools and Approaches for Nanomaterial Safety Assessment, Malaga, Spain, February 7 – 9, 2017

2016

Studying the biological effects of combustion aerosols on air/liquid-interface exposed human and murine lung cells within the HICE-project: Composition and molecular biological effects of emissions from wood combustion, ship emissions and car engines
Zimmermann, R.; Dittmar, T. G.; Kanashova, T.; Buters, J.; Öder, S.; Paur, H.; Schlager, C.; Mülhopt, S.; Dilger, M.; Weiß, C.; Diabate, S.; Harndorf, H.; Stengel, B.; Rabe, R.; Hiller, K.; Sapccariu, S. C.; BeruBe, K. A.; Wlodarcyzk, A. J.; Michalke, B.; Krebs, T.; Kelbg, M.; Tiggesbäumker, J.; Streibel, T.; Karg, E.; Scholtes, S.; Schnelle-Kreis, J.; Lintelmann, J.; Sklorz, M.; Arteaga Salas, M.; Klingbeil, S.; Orasche, J.; Richthammer, P.; Müller, L.; Rheda, A.; Passig, J.; Gröger, T.; Abbaszade, G.; Radischat, C.; Smita, S.; Orasche, J.; Torvela, T.; Titta, P.; Kortelainen, M.; Lamberg, H.; Tissari, J.; Leskinen, A.; Jalava, P.; Hirvonen, M. R.; Kasurinen, S.; Jalava, P.; Sippula, O.; Jokiniemi, J.
2016. 22nd European Aerosol Conference (EAC), Tours, F, September 4-9, 2016. Proceedings on USB-Stick

A lab scale measurement technique for the air-liquid interface exposure of human lung cell cultures towards particulate emissions from combustion processes
Mülhopt, S.; Dilger, M.; Diabate, S.; Schlager, C.; Krebs, T.; Zimmermann, R.; Buters, J.; Oeder, S.; Weiss, C.; Paur, H. R.
2016. 11th International Particle Toxicology Conference (IPTC 2016), Singapore, SGP, September 26-30, 2016

Reproducible aerosol generation for mass balance studies and dosimetry investigation with low particle masses
Mülhopt, S.; Schlager, C. H.; WIlson, K.; Paur, H. R.
2016. 22nd European Aerosol Conference (EAC), Tours, F, September 4-9, 2016. Proceedings on USB-Stick

Effects of cerium oxide nanoparticle aerosol on human lung cells exposed at the Air-Liquid-Interface
Mülhopt, S.; Diabate, S.; Schlager, C.; Murugadoss, S.; Dilger, M.; Weiss, C.; Krebs, T.; Tang, S.; Gooden, P.; Paur, H. R.
2016. 22nd European Aerosol Conference (EAC), Tours, F, September 4-9, 2016.Proceedings on USB-Stick

Metabolic Profiling as Well as Stable Isotope Assisted Metabolic and Proteomic Analysis of RAW 264.7 Macrophages Exposed to Ship Engine Aerosol Emissions: Different Effects of Heavy Fuel Oil and Refined Diesel Fuel
Sapcariu, S. C.; Kanashova, T.; Dilger, M.; Diabaté, S.; Oeder, S.; Passig, J.; Radischat, C.; Buters, J.; Sippula, O.; Streibel, T.; Paur, H.-R.; Schlager, C.; Mülhopt, S.; Stengel, B.; Rabe, R.; Harndorf, H.; Krebs, T.; Karg, E.; Gröger, T.; Weiss, C.; Dittmar, G.; Hiller, K.; Zimmermann, R.
2016. PLoS one, 11 (6), e0157964. doi:10.1371/journal.pone.0157964

Nanoparticles on human lung cells. The vitrocell exposure system for cell cultures at the air-liquid interface
Mülhopt, S.; Krebs, T.; Diabate, S.; Schlager, C.; Paur, H.-R.
2016. Labor&more International Edition, 2016 (2), 14–19

Effects of cerium oxide nanoparticle aerosol on human lung cells exposed at the Air-Liquid-Interface
Mülhopt, S.; Diabate, S.; Schlager, C.; Murugadoss, S.; Dilger, M.; Weiss, C.; Krebs, T.; Tang, S.; Gooden, P.; Paur, H. R.
2016. Air-Liquid Interface Workshop, Paris, March 21, 2016

Toxicity testing of combustion aerosols at the air-liquid interface with a self-contained and easy-to-use exposure system
Mülhopt, S.; Dilger, M.; Diabate, S.; Schlager, C.; Krebs, T.; Zimmermann, R.; Buters, J.; Oeder, S.; Waescher, T.; Weiss, C.; Paur, H.-R.
2016. Journal of Aerosol Science, 96, 38–55. doi:10.1016/j.jaerosci.2016.02.005

2015

Automatisierte und definierte Deposition von Aerosolen auf Zellkulturen für eine Bewertung der biologischen Wirksamkeit von Feinstäuben
Mülhopt, S.; Diabate, S.; Schlager, C.; Dilger, M.; Krebs, T.; Weiss, C.; Paur, H. R.
2015. Fachtagung Neue Entwicklungen bei der Messung und Beurteilung der Luftqualität, Nürnberg, 20.-21.Oktober 2015

Automatisierte und definierte Deposition von Aerosolen auf Zellkulturen für eine Bewertung der biologischen Wirksamkeit von Feinstäuben
Mülhopt, S.; Diabate, S.; Schlager, C.; Dilger, M.; Krebs, T.; Weiss, C.; Paur, H. R.
2015. Neue Entwicklungen bei der Messung und Beurteilung der Luftqualität : Nürnberg, 20. und 21.Oktober 2015, 243–247, VDI Verlag

A lab scale measurement technique for the air-liquid-interface exposure of human lung cell cultures towards airborne particles
Mülhopt, S.; Diabate, S.; Schlager, C.; Murugadoss, S.; Dilger, M.; Weiss, C.; Krebs, T.; Paur, H. R.
2015. European Aerosol Conference 2015 (EAC 2015), Milano, I, September 6-11, 2015

Biological effects of combustion aerosols on human lung cells exposed at the air liquid interface: Comparison of the molecular biological effects of log wood and pellet combustion aerosols with the effect of ship engine emissions
Zimmermann, R.; Dittmar, T. G.; Kanashova, T.; Buters, J.; Öder, S.; Paur, H.; Schlager, C.; Mülhopt, S.; Dilger, M.; Weiß, C.; Diabate, S.; Harndorf, H.; Stengel, B.; Rabe, R.; Hiller, K.; Sapccariu, S. C.; BerBe, K. A.; Wlodarcyzk, A. J.; Michalke, B.; Krebs, T.; Kelbg, M.; Tiggesbäumker, J.; Streibel, T.; Karg, E.; Scholtes, S.; Schnelle-Kreis, J.; Lintelmann, J.; Sklorz, M.; Arteaga Salas, M.; Klingbeil, S.; Orasche, J.; Richthammer, P.; Müller, L.; Rheda, A.; Passig, J.; Gröger, T.; Abbaszade, G.; Radischat, C.; Smita, S.; Orasche, J.; Torvela, T.; Tiitta, P.; Yli-Pirilä, P.; Kortelainen, M.; Leskinen, J.; Lamberg, H.; Grigonyte, J.; Tissari, J.; Leskinen, A.; Kuuspalo, K.; Hao, L.; Kasurinen, S.; Jalava, P.; Lehtinen, K.; Virtanen, A.; Hirvonen, M. R.; Kasurinen, S.; Jalava, P.; Sippula, O.; Jokiniemi, J.
2015. European Aerosol Conference 2015 (EAC 2015), Milano, I, September 6-11, 2015

Is the deposited dose in an air-liquid-interface exposure system comparable to the human lungs?
Karg, E. W.; Ferron, G. A.; Mülhopt, S.; Paur, H. R.; Zimmermann, R.
2015. 20th International Congress on Aerosols in Medicine and Pulmonary Drug Delivery (ISAM 2015), München, May 30 - June 3, 2015 Journal of Aerosol Medicine and Pulmonary Drug Delivery, 28(2015) No.3, A34 (Abstract)

Synthesis, variability and stability of nanoparticles
Paur, H. R.; Mahon, E.; Lynch, I.; Bergfeldt, T.; Diabate, S.; Forsgren, J.; Mülhopt, S.; Bagaria, J. P.; Puntes, V.; Schneider, R.; Weiss, C.; Wilkins, T.; Jiang, Y.
2015. QualityNano Conference, Heraklion, GR, July 15-17, 2015

Dose determination in the air-liquid interface exposure of cell cultures for in vitro toxicological studies
Mülhopt, S.; Krebs, T.; Paur, H. R.
2015. Aerosol Technology 2015, Tampere, SF, June 15-17, 2015

A lab scale measurement technique for the air-liquid interface exposure of human lung cell cultures towards airborne nanoparticles
Mülhopt, S.; Dilger, M.; Diabate, S.; Schlager, C.; Krebs, T.; Weiss, C.; Paur, H. R.
2015. EuroNanoForum 2015, Riga, LV, June 10-12, 2015

A lab scale measurement device for the air-liquid interface exposure cultured lung cells towards wood burning emissions
Mülhopt, S.; Dilger, M.; Schlager, C.; Krebs, T.; Diabaté, S.; Weiss, C.; Paur, H.-R.
2015. Energy, Science and Technology, Conference and Exhibition (EST 2015), Karlsruhe, Germany, May 20–22, 2015

Particulate matter from both heavy fuel oil and diesel fuel shipping emissions show strong biological effects on human lung cells at realistic and comparable in vitro exposure conditions
Oeder, S.; Kanashova, T.; Sippula, O.; Sapcariu, S. C.; Streibel, T.; Arteaga-Salas, J. M.; Passig, J.; Dilger, M.; Paur, H. R.; Schlager, C.; Mülhopt, S.; Diabate, S.; Weiss, C.; Stengel, B.; Rabe, R.; Harndorf, H.; Torvela, T.; Jokiniemi, J. K.; Hirvonen, M. R.; Schmidt-Weber, C.; Traidl-Hoffmann, C.; BeruBe, K. A.; Wlodarczyk, J.; Prytherch, Z.; Michalke, B.; Krebs, T.; Prevot, A. S. H.; Kelbg, M.; Tiggesbäumker, J.; Karg, E.; Jakobi, G.; Scholtes, S.; Schnelle-Kreis, J.; Lintelmann, J.; Matuschek, G.; Sklorz, M.; Klingbeil, S.; Orasche, J.; Richthammer, P.; Müller, L.; Elsasser, M.; Reda, A.; Gröger, T.; Weggler, B.; Czech, H.; Rüger, C. P.; Abbaszade, G.; Radischat, C.; Hiller, K.; Buters, J. T. M.; Dittmar, G.; Zimmermann, R.; Schwemer, T.
2015. PLoS one, 10 (6), e126536. doi:10.1371/journal.pone.0126536

A lab scale measurement device for the air-liquid interface exposure cultured lung cells towards wood burning emissions
Mülhopt, S.; Dilger, M.; Schlager, C.; Krebs, T.; Diabate, S.; Weiss, C.; Paur, H. R.
2015. EST 2015 - Energy, Science and Technology, Karlsruhe, May 20-22, 2015

A lab scale measurement technique for the air-liquid interface exposure of human lung cell cultures towards airborne nanoparticles
Mülhopt, S.; Diabate, S.; Schlager, C.; Dilger, M.; Weiss, C.; Krebs, T.; Paur, H.
2015. 20th International Congress on Aerosols in Medicine and Pulmonary Drug Delivery (ISAM 2015), München, May 30 - June 3, 2015 Journal of Aerosol Medicine and Pulmonary Drug Delivery, 28( 2015) No.3, A30 (Abstract)

Feinstaub in der Lunge. Automatisiertes Expositionssystem für Zellkulturen an der Gas-Flüssigkeits-Grenzschicht
Mülhopt, S.; Krebs, T.; Diabate, S.; Schlager, C.; Paur, H. R.
2015. Labor&More, (2), 32–37

The Karlsruhe exposure system for assessment of lung toxicity of airborne submicron particles
Mülhopt, S.; Schlager, C.; Diabate, S.; Krebs, T.; Paur, H. R.
2015. NanoVision Symposium, Stuttgart, January 22-23, 2015

Particle characterization at the air-liquid interface
Paur, H. R.; Mülhopt, S.
2015. NanoVision Symposium, Stuttgart, January 22-23, 2015

2014

Poster Session Group III
Oeder, S.; Sippula, O.; Streibel, T.; Paur, H.-R.; Mülhopt, S.; Arteaga, M.; Harndorf, H.; Zimmermann, R.; Schmidt-Weber, C.; Buters, J. T. M.
2014. Allergy, 69, 454–572. doi:10.1111/all.12478

Silica nanoparticles are less toxic to human lung cells when deposited at the air-liquid interface compared to conventional submerged exposure
Panas, A.; Comouth, A.; Saathoff, H.; Leisner, T.; Al-Rawi, M.; Simon, M.; Seemann, G.; Dössel, O.; Mülhopt, S.; Paur, H.-R.; Fritsch-Decker, S.; Weiss, C.; Diabaté, S.
2014. Beilstein journal of nanotechnology, 5 (1), 1590–1602. doi:10.3762/bjnano.5.171

Titanium dioxide nanoparticles toxicology: Towards more physiological in vitro exposure models?
Armand, L.; Biola-Clier, M.; Dilger, M.; Mülhopt, S.; Schlager, C.; Paur, H. R.; Collin-Faure, V.; Diabate, S.; Weiss, C.; Herlin-Biome, N.; Rabilloud, T.; Carriere, M.
2014. 4th International Conference on Safe Production and Use of Nanomaterials (NANOSAFE), Grenoble, F, November 18-20, 2014

Toxic effects of nanoparticles from biomass combustion
Weise, F.; Baumbach, G.; Dreher, W. F.; Houas, E.; Klostermann, J.; Mülhopt, S.; Paur, H. R.; Schlager, C.; Struschka, M.; Warres, C.; Winter, P.
2014. 18th ETH-Conference on Combustion Generated Nanoparticles, Zürich, CH, June 22-25, 2014

Air-liquid interface exposure system for in vitro toxicological studies of combustion derived ultrafine aerosols
Mülhopt, S.; Dilger, M.; Schlager, C.; Zimmermann, R.; Diabate, S.; Weiss, C.; Paur, H. R.
2014. Conference on Aerosol Technology, Karlsruhe, June 16-18, 2014 Book of Abstracts T260A02

Air-liquid interface exposure system for in vitro toxicological studies of airborne nanoparticles
Mülhopt, S.; Dilger, M.; Schlager, C.; Diabate, S.; Braakhuis, H.; Weiss, C.; Paur, H. R.
2014. 7th International Nanotoxicology Congress (NanoTox 2014), Antalya, TR, April 23- 26, 2014 Book of Abstracts

Batch-to-batch reproducibility - a challenge for safety assessment and regulation
Mülhopt, S.; Paur, H. R.; Adelhelm, C.; Diabate, S.; Forsgren, J.; Mahon, E.; Bagaria, J. P.; Puntes, V.; Schneider, R.; Wilkins, T.; Jiang, Y.; Weiss, C.
2014. 7th International Nanotoxicology Congress (NanoTox 2014), Antalya, TR, April 23- 26, 2014 Book of Abstracts

Air-liquid interface exposure for in vitro toxicological studies - Numerical simulation of particle deposition for dose assessment
Mülhopt, S.; Krebs, T.; Paur, H. R.
2014. 2014 International Aerosol Conference (IAC 2014), Busan, Korea, August 28 - September 2, 2014

A comprehensive study on the composition of aerosol emissions from ship-diesel engines operated with diesel fuel or heavy fuel oil
Schnelle-Kreis, J.; Dittmar, T. G.; Kanashova, T.; Buters, J.; Öder, S.; Paur, H.; Schlager, C.; Mülhopt, S.; Dilger, M.; Weiß, C.; Diabate, S.; Harndorf, H.; Stengel, B.; Rabe, R.; Hirvonen, M. R.; Jokiniemi, J.; Torvela, T.; Hiller, K.; Sapccariu, S. C.; BeruBe, K. A.; Wlodardcyzk, A. J.; Sippula, O.; Michalke, B.; Krebs, T.; Kelbg, M.; Tiggesbäumker, J.; Streibel, T.; Karg, E.; Scholtes, S.; Lintelmann, J.; Matuschek, G.; Sklorz, M.; Arteaga Salas, M.; Klingbeil, S.; Orasche, J.; Richthammer, P.; Müller, L.; Elsasser, M.; Rheda, A.; Passig, J.; Gröger, T.; Abbaszade, G.; Radischat, C.; Zimmermann, R.
2014. 2014 International Aerosol Conference (IAC 2014), Busan, Korea, August 28 - September 2, 2014

A comprehensive study on the composition and the biological/health-effects of aerosol emission from ship-diesel engines operated with diesel fuel of heavy fuel oil
Zimmermann, R.; Dittmar, T. G.; Kanashova, T.; Buters, J.; Öder, S.; Paur, H.; Schlager, C.; Mülhopt, S.; Dilger, M.; Weiß, C.; Diabate, S.; Harndorf, H.; Stengel, B.; Rabe, R.; Hirvonen, M. R.; Jokiniemi, J.; Torvela, T.; Hiller, K.; Sapccariu, S. C.; BeruBe, K. A.; Wlodarcyzk, A. J.; Sippula, O.; Michalke, B.; Krebs, T.; Kelbg, M.; Tiggesbäumker, J.; Streibel, T.; Karg, E.; Scholtes, S.; Schnelle-Kreis, J.; Lintelmann, J.; Matuschek, G.; Sklorz, M.; Arteaga Salas, M.; Klingbeil, S.; Orasche, J.; Richthammer, P.; Müller, L.; Elasasser, M.; Rheda, A.; Passig, J.; Gröger, T.; Abbaszade, G.; Radischat, C.
2014. 2014 International Aerosol Conference (IAC 2014), Busan, Korea, August 28 - September 2, 2014

2013

Air-liquid interface exposure system for in vitro toxicological studies of wood combustion aerosols
Mülhopt, S.; Dilger, M.; Schlager, C.; Zimmermann, R.; Diabate, S.; Weiss, C.; Paur, H. R.
2013. European Aerosol Conference (EAC 2013), Praha, CZ, September 1-6, 2013

Air-liquid interface exposure systems for the assessment of toxicity of combustion aerosols
Paur, H. R.; Mülhopt, S.; Dilger, M.; Schlager, C.; Krebs, T.; Zimmermann, R.; Diabate, S.; Weiss, C.
2013. European Aerosol Conference (EAC 2013), Praha, CZ, September 1-6, 2013

Health relevant compounds in wood combustion and ship diesel aerosols: evaluation of the toxicity due to polycyclic aromatic hydrocarbons
Orasche, J.; Dittmar, T. G.; Kanashova, T.; Buters, J.; Öder, S.; Paur, H.; Schlager, C.; Mülhopt, S.; Dilger, M.; Weiß, C.; Diabate, S.; Harndorf, H.; Stengel, B.; Rabe, R.; Hiller, K.; Sapccariu, S. C.; BeruBe, K. A.; Wlodarcyzk, A. J.; Sippula, O.; Jokiniemi, J.; Hirvonen, M. R.; Michalke, B.; Krebs, T.; Kelbg, M.; Tiggesbäumker, J.; Streibel, T.; Karg, E.; Abbaszade, G.; Scholtes, S.; Schnelle-Kreis, J.; Lintelmann, J.; Sklorz, M.; Areaga Salas, M.; Klingbeil, S.; Richthammer, P.; Müller, L.; Elsasser, M.; Rheda, A.; Werner, B.; Passig, J.; Gröger, T.; Radischat, C.; Zimmermann, R.
2013. European Aerosol Conference (EAC 2013), Praha, CZ, September 1-6, 2013

Batch-to-batch reproducibility - A challenge for safety assessment and regulation
Paur, H. R.; Adelhelm, C.; Diabate, S.; Forsgren, J.; Mahon, E.; Mülhopt, S.; Bagaria, J. P.; Puntes, V.; Schneider, R.; Weiss, C.; Wilkins, T.; Jiang, Y.
2013. European Aerosol Conference (EAC 2013), Praha, CZ, September 1-6, 2013

Modelling and measurement of particle deposition for cell exposure at the air-liquid interface
Comouth, A.; Saathoff, H.; Naumann, K.-H.; Muelhopt, S.; Paur, H.-R.; Leisner, T.
2013. Journal of aerosol science, 63, 103–114. doi:10.1016/j.jaerosci.2013.04.009

Air-liquid interface (ALI) exposure system for in vitro toxicological studies of combustion aerosols in the HICE project
Dilger, M.; Mülhopt, S.; Schlager, C.; Zimmermann, R.; Orasche, J.; Diabate, S.; Weiss, C.; Krebs, T.; Paur, H. R.
2013. Ultrafine Particles : Sources, Effects, Risks and Mitigation Strategies ; EFCA Internat.Symp., Bruxelles, B, May 16-17, 2013

Air-liquid interface (ALI) exposure system for in vitro toxicological studies of combustion aerosols in the HICE project
Dilger, M.; Mülhopt, S.; Schlager, C.; Zimmermann, R.; Orasche, J.; Diabate, S.; Weiss, C.; Krebs, T.; Paur, H. R.
2013. Ultrafine Particles: Sources, Effects, Risks and Mitigation Strategies. EFCA International Symposium, Bruxelles, B, May 16-17, 2013, Karlsruher Institut für Technologie (KIT)

Toxicity profiling of wood combustion and ship diesel engine exhausts by air-liquid interface exposure
Dilger, M.; Mülhopt, S.; Schlager, C.; Paur, H. R.; Orasche, J.; Zimmermann, R.; Diabate, S.; Weiss, C.
2013. Aerosol Emissions from Fossil Fuel and Biomass Combustion : Chemical Properties, Transformation and Health Effects, Praha, CZ, August 31- September 1, 2013

Studying the causes of health effects of combustion-derived aerosols in the framework of the virtual Helmholtz institute HICE: First results on ship diesel and wood combustion aerosols
Zimmermann, R.; Dittmar, T. G.; Kanashova, T.; Buters, J.; Öder, S.; Paur, H.; Schlager, C.; Mülhopt, S.; Dilger, M.; Weiss, C.; Diabate, S.; Harndorf, H.; Stengel, B.; Rabe, R.; Hirvonen, M. R.; Jokiniemi, J.; Torvela, T.; Hiller, K.; Sapccariu, S. C.; BeruBe, K. A.; Wlodarcyzk, A. J.; Sippula, O.; Michalke, B.; Krebs, T.; Kelbg, M.; Tiggesbäumker, J.; Streibel, T.; Karg, E.; Scholtes, S.; Schnelle-Kreis, J.; Lintelmann, J.; Sklorz, M.; Arteaga Salas, M.; Klingbeil, S.; Orasche, J.; Richthammer, P.; Müller, L.; Elsasser, M.; Rheda, A.; Werner, B.; Passig, J.; Gröger, T.; Abbaszade, G.; Radischat, C.
2013. European Aerosol Conference (EAC 2013), Praha, CZ, September 1-6, 2013

Exposure of A549 cells to SiO₂-NPs under submerged conditions and at the air-liquid interface using the Karlsruhe exposure system (KIT-TAF)
Stoehr, L. C.; Diabate, S.; Kielmeier, U.; Mülhopt, S.; Paur, H. R.; Weiss, C.; Oostingh, G. J.; Duschl, A.
2013. 2nd QNano Integrating Conference, Praha, CZ, February 27 - March 1, 2013

Screening of different metal oxide nanoparticles reveals selective toxicity and inflammatory potential of silica nanoparticles in lung epithelial cells and macrophages
Panas, A.; Marquardt, C.; Nalcaci, O.; Bockhorn, H.; Baumann, W.; Paur, H. R.; Mülhopt, S.; Diabate, S.; Weiss, C.
2013. Nanotoxicology, 7 (3), 259–273. doi:10.3109/17435390.2011.652206

Regulation of the arachidonic acid mobilization in macrophages by combustion-derived particles
Fritsch-Decker, S.; Both, T.; Mülhopt, S.; Paur, H. R.; Weiss, C.; Diabate, S.
2013. Jahrestagung der Deutschen Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie (DGPT), Halle, 5.-7. März 2013

2012

A novel exposure system for testing the lung toxicity of domestic wood combustion aerosols
Mülhopt, S.; Gauggel, S.; Schlager, C.; Schröder, T.; Paur, H. R.
2012. Aerosols from Domestic Biomass Heating : Satellite Workshop within the European Aerosol Conf. (EAC 2011), Manchester, GB, September 4-9, 2011, 37–38

Exposure of A549 cells to SiO₂ nanoparticles under submerged conditions and at the air-liquid interphase
Panas, A.; Diabate, S.; Comouth, A.; Saathoff, H.; Paur, H. R.; Mülhopt, S.; Weiss, C.
2012. BWTOX Symposium, Karlsruher Institut für Technologie, 23. November 2012

New methods for evaluating modern domestic small scale biomass furnaces by considering the toxicity of their particulate matter emissions
Schröder, T.; Lenz, V.; Mülhopt, S.; Paur, H. R.; Gauggel, S.; den Burg, B. van; Dietrich, D. R.
2012. 4th Internat.Symp.on Energy from Biomass and Waste (Venice 2012), Venezia, I, November 12-15, 2012

Toxicity testing of domestic wood combustion aerosols
Mülhopt, S.; Gauggel, S.; Dietrich, D. R.; Schröder, T.; Burg, B. van der; Paur, H. R.
2012. European Aerosol Conf. (EAC 2012), Granada, E, September 2-7, 2012

Batch-to-batch-variability of Stöber synthesized SiO₂ nanoparticles. Comparison of DLS and SMPS data within q-Nano
Mülhopt, S.; Hauser, M.; Mahon, E.; Schneider, R.; Paur, H. R.
2012. European Aerosol Conf. (EAC 2012), Granada, E, September 2-7, 2012